（For Research Use Only）

BACKGROUND

Pharmacogenomics is a discipline that studies the relationship between genetic variations and drug responses, with the goal of improving drug efficacy and safety. It investigates the genetic characteristics that affect individual differences in drug absorption, distribution, metabolism, and elimination, as well as the different responses to drugs caused by genetic variations in different patients. By doing so, it provides a platform for developing new drugs, guiding rational drug use, enhancing drug effectiveness, reducing adverse drug reactions, lowering the overall cost of drug development, and ultimately improving the quality of disease treatment.

Differences in drug-metabolizing enzymes and drug target genotype can affect the drug's in vivo concentration and the sensitivity of targeted tissues to the drug, resulting in individual differences in drug responsiveness (including therapeutic and adverse reactions). 

This test kit detects 40 SNP loci of 24 pharmacogenomic-related genes, which can guide patients with specific genotypes to select appropriate drugs and dosages, achieve personalized medication, and improve the effectiveness and safety of drug therapy, thereby preventing the occurrence of serious adverse drug reactions.

DETECTED GENES

PRODUCT INFORMATION

DETECTION SIGNIFICANCE

1. Guide clinical practice to select appropriate medications and dosages tailored to specific patients, achieving personalized drug therapy.

2. Enhance the efficacy and safety of drug therapy and prevent the occurrence of serious adverse drug reactions.

ELIGIBLE POPULATION

1. Patients requiring long-term or lifelong drug therapy, such as cardiovascular drugs, antipsychotic drugs, gastrointestinal drugs, etc.

2. Individuals with a history of serious adverse drug reactions or a family member with such a history.

3. Patients receiving multiple drug therapies simultaneously.

4. Patients whose use of a certain drug has not achieved the desired clinical outcome, and whose disease control is unstable.

FEATURES & ADVANTAGES

1. Ease of Use: Using the combination of PCR in vitro amplification and MassARRAY^® mass spectrometry, highly multiplexed reactions can be achieved under universal cycling conditions, and the instrument can automatically complete desalting and spotting operations.

2. Fast Results: Simple and clear bioinformatics analysis and multiple sample testing greatly reduce the total running time and simplify the data processing process. With a small amount of manual operation time, results can be obtained within one day.

3. Comprehensive Testing: The simultaneous detection of 24 target genes and 40 loci provides comprehensive guidance for clinicians to select appropriate drugs and dosage for individualized treatment of specific patients.

DETECTION PROCESS

1. DNA Extraction

2. Template Addition

3. Mass Spectrometry Analysis

4. Data Analysis

5. Report generation