Methodology

‍‍‍Technical‍‍‍

‍‍Technical Characteristic‍‍

Traditional cervical 

smear ( Pap Smear)

Scrape the epithelial cells in the cervix 

with a scraper, apply evenly on the glass 

slide,fix and stain.

Lower cost: Due to human factors in the 

acquisition, production, and reading, the 

results are limited. 

This method has gradually been eliminated.

Thinprep cytologic 

test（TCT）

The obtained exfoliated cells from cervical secretions are collected and immersed 

in liquid cell processing reagents, and 

then exfoliated cell slices are made. After staining, the cell morphology of the 

cervix can be checked by manual 

observation and analysis to diagnose 

cervical cancerand itsprecancerous 

changes. 

Convenient sampling and breakthrough in 

production technology; Need manual 

observation and analysis of cell morphology. 

Easy to be interfered by human factors.

The diagnosis rate of atypical squamous cell

smear is not high, often unable to detect 

cervical cancer.

Human

 papillomavirus 

(HPV) testing

‍‍Use DNA amplification and hybridization 

technology to detect cervical cell 

samples for HPV infection status and 

typing, Mainly focus on the typing of 

high-risk HPV (hr-HPV) such as 16 and 18.

‍

High throughput and sensitivity.Can detect 

multiple infections, suitable for large-scale 

clinical screening.Detection of viruses instead 

of individual genes. Only early warning rather 

than earlydetection.

There is a possibility for false positive.

PAX1 methylation 

detection

‍‍Detect cervical smear samples for the 

high-level sensitivity and specify of PAX1 

gene Methylation.‍‍

‍‍Accurate screening at the individual genetic 

level, safe and reliable.High throughput and 

sensitivity, strong specificity.The operation is 

automatic and good repeatability.

Molecular

Cytologic

Visual Inspection

Nucleic acid amplification tests

 (NAAT)

» high-risk HPV DNA/NAAT

» mRNA

DNA methylation

Protein biomarkers

» HPV antibodies

» oncoproteins

Conventional Pap smear

Liquid-based cytology (LBC)

Dual staining to identify p16 and 

Ki-67

Visual inspection with acetic acid or with 

Lugol’s iodine (VIA/VILI)

» naked eye

» magnified by 

colposcope or camera 

Automated visual 

evaluation of digital images

‍‍‍Methodology‍‍‍

‍‍PAP-ARMS^® Technology ‍‍

‍‍Applicable people‍‍

● ‍‍Cervical cancer screening or regular assessment‍‍

● HPV positive carrier

● Patients with abnormal cervical smear test

● Cervical spine incision, cervical surgery, patient monitoring after 

radiotherapy and chemotherapy

● People with unexplained vaginal bleeding

Technological Breakthrough

● New  biomarkers of cervical cancer

● High specificity and sensitivity

● The operation is automatic, simple ,fast, and with good repeatability

● Independent screening, safe and reliable

Product Name

Core Technology

Pack Size

Instruments Validated

Sample Type

Human PAX1 Gene 

Methylation Detection Kit

PAP-ARMS^®

24 Tests/Kit 

Stratagene Mx3000P™

ABI7500 etc.

Cervical scraping